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Beyond Weight Loss: 7 Potential Health Benefits of Semaglutide
If you're curious about semaglutide, you're not alone — it’s known for weight loss, but that’s not all semaglutide offers.
Semaglutide belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. It has several medical purposes, and that’s what the Performance Rejuvenation Center team highlights here.
There are seven potential health benefits of semaglutide.
1. Improved heart and vascular health
Semaglutide can significantly reduce your risk of major cardiovascular events — like heart attacks, strokes, or death from heart-related issues — by about 20%, even if your blood sugar is in the healthy range.
2. Lower blood sugar levels
Semaglutide treats type 2 diabetes. It helps improve insulin levels in your body. When you have plenty of insulin doing its job — pulling glucose out of your bloodstream and into your cells — your blood sugar levels go down.
This process helps your blood glucose levels and reduces the risk of diabetes. Diabetes, left untreated or undermanaged, can lead to serious complications, including vision issues, kidney issues, and even problems with your feet.
3. Kidney protection
In people with type 2 diabetes and existing kidney problems, semaglutide lowered the risk of severe kidney outcomes, such as kidney failure or death.
4. Lowered inflammation
Semaglutide helps reduce inflammation, regardless of whether you have lost weight or not. Inflammation is at the root of many conditions, and so lowering systemic inflammation may support heart and overall metabolic health.
5. Liver benefits
According to a June 2025 study published in The New England Journal of Medicine, semaglutide may help slow or reverse fatty liver disease by reducing liver fat, inflammation, and scarring.
Researchers found that a weekly injection of 2.4 milligrams of semaglutide can also help metabolic dysfunction-associated steatohepatitis (MASH), a fatty liver condition related to obesity or diabetes.
6. Mood and brain health
Semaglutide has neuroprotective and mood-improving effects, including potential support for depression, and is being studied in pre-clinical models for Alzheimer’s and addiction.
7. Better joint comfort and mobility
Semaglutide may reduce knee pain and improve function in people with osteoarthritis. According to a clinical trial published in The New England Journal of Medicine, people in the semaglutide group experienced more pain relief with a once-weekly injection.
How to use semaglutide
Semaglutide is taken as a once-weekly injection, usually under the skin in your stomach, thigh, or upper arm. It’s important to follow the dosing schedule that Dr. Tyson gives you, especially when starting. Most people start with a low dose to reduce side effects and slowly increase it.
How Performance Rejuvenation Center can support you
Performance Rejuvenation Center may prescribe semaglutide to support your health beyond weight loss. We blend it with personalized lifestyle coaching, covering nutrition, exercise, and stress reduction as part of our holistic men’s health programs.
The best part? Because we operate on a HIPAA-compliant telehealth platform, we can help men reach their health goals in most US states.
Is semaglutide right for you?
Book a consultation to determine if semaglutide benefits your health goals. Call us at 202-251-4472. You can also schedule a consultation online anytime.